Biology:Salt-inducible kinase

From HandWiki

Salt-inducible kinases, also known as SIK enzymes, are a family of proteins found in most animal species. They are a type of serine-threonine kinase enzymes. They were originally isolated from the adrenal glands of rats fed with a high-salt diet. SIK enzymes are part of a system of proteins which act as a sensor of intracellular sodium levels and activate the Na(+),K(+)-ATPase to expel excess sodium from the cytosol, which is then excreted in urine by the kidneys. There are three subtypes, SIK1, SIK2 and SIK3. SIK1 is induced by cAMP and represses the activity of CRE-binding protein (CREB). SIK1 is also involved with regulating steroidogenic enzyme production during steroidogenesis. In recent years, SIK enzymes have attracted interest as a potential target for anti-cancer drugs,[1] as well as playing a role in other processes such as hypertension and acute kidney injury. They are also involved in the tanning response following UV exposure.[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]

Inhibitors

References

  1. ↑ "SIK2 inhibition enhances PARP inhibitor activity synergistically in ovarian and triple-negative breast cancers". Journal of Clinical Investigation 132 (11). 2022. doi:10.1172/JCI146471. PMID 35642638. PMC 9151707. https://doi.org/10.1172/JCI146471. 
  2. ↑ "Salt-inducible kinase in steroidogenesis and adipogenesis". Trends in Endocrinology and Metabolism 15 (1): 21–26. 2004. doi:10.1016/j.tem.2003.11.002. PMID 14693422. 
  3. ↑ "Regulation of CREB-mediated gene expression by salt inducible kinase". The Journal of Steroid Biochemistry and Molecular Biology 108 (3–5): 287–291. February 2008. doi:10.1016/j.jsbmb.2007.09.006. PMID 17935972. 
  4. ↑ "Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1802 (12): 1140–1149. December 2010. doi:10.1016/j.bbadis.2010.03.009. PMID 20347966. 
  5. ↑ "cAMP stimulation of StAR expression and cholesterol metabolism is modulated by co-expression of labile suppressors of transcription and mRNA turnover". Molecular and Cellular Endocrinology 336 (1–2): 53–62. April 2011. doi:10.1016/j.mce.2010.12.006. PMID 21147196. 
  6. ↑ "The diverse oncogenic and tumor suppressor roles of salt-inducible kinase (SIK) in cancer". Expert Opinion on Therapeutic Targets 20 (4): 477–485. 2016. doi:10.1517/14728222.2016.1101452. PMID 26549013. 
  7. ↑ "Gene Level Regulation of Na,K-ATPase in the Renal Proximal Tubule Is Controlled by Two Independent but Interacting Regulatory Mechanisms Involving Salt Inducible Kinase 1 and CREB-Regulated Transcriptional Coactivators". International Journal of Molecular Sciences 19 (7): 2086. July 2018. doi:10.3390/ijms19072086. PMID 30021947. 
  8. ↑ "Salt-Inducible Kinase 2: An Oncogenic Signal Transmitter and Potential Target for Cancer Therapy". Frontiers in Oncology 9. 2019. doi:10.3389/fonc.2019.00018. PMID 30723708. 
  9. ↑ "Salt Inducible Kinase Signaling Networks: Implications for Acute Kidney Injury and Therapeutic Potential". International Journal of Molecular Sciences 20 (13): 3219. June 2019. doi:10.3390/ijms20133219. PMID 31262033. 
  10. ↑ "The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis". Signal Transduction and Targeted Therapy 5 (1). August 2020. doi:10.1038/s41392-020-00265-w. PMID 32788639. 
  11. ↑ "Nuts and bolts of the salt-inducible kinases (SIKs)". The Biochemical Journal 478 (7): 1377–1397. April 2021. doi:10.1042/BCJ20200502. PMID 33861845. 
  12. ↑ "Skin pigmentation and its control: From ultraviolet radiation to stem cells". Experimental Dermatology 30 (4): 560–571. April 2021. doi:10.1111/exd.14260. PMID 33320376. 
  13. ↑ "Salt-inducible kinases: new players in pulmonary arterial hypertension?". Trends in Pharmacological Sciences 43 (10): 806–819. October 2022. doi:10.1016/j.tips.2022.06.008. PMID 35851157. 
  14. ↑ "The multiple roles of salt-inducible kinases in regulating physiology". Physiological Reviews 103 (3): 2231–2269. July 2023. doi:10.1152/physrev.00023.2022. PMID 36731029. 
  15. ↑ "Roles of salt‑inducible kinases in cancer (Review)". International Journal of Oncology 63 (5). November 2023. doi:10.3892/ijo.2023.5566. PMID 37654200. 
  16. ↑ "The Complex Interplay between Nevi and Melanoma: Risk Factors and Precursors". International Journal of Molecular Sciences 24 (4): 3541. February 2023. doi:10.3390/ijms24043541. PMID 36834954. 
  17. ↑ "Understanding the roles of salt-inducible kinases in cardiometabolic disease". Frontiers in Physiology 15. 2024. doi:10.3389/fphys.2024.1426244. PMID 39081779. 
  18. ↑ "Salt-inducible kinases (SIKs) in cancer: mechanisms of action and therapeutic prospects". Drug Discovery Today 30 (1). January 2025. doi:10.1016/j.drudis.2024.104279. PMID 39710233. 
  19. ↑ "Central and Peripheral Roles of Salt-inducible Kinases in Metabolic Regulation". Endocrinology 166 (3). February 2025. doi:10.1210/endocr/bqaf024. PMID 39919030. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Biology:Salt-inducible_kinase&oldid=4071701"